Quiz: Pharma (NSAIDs & SAIDs )

The analgesic of choice for toothache in patients suffering from peptic ulcer 'is

A a-methyl salicylate B b-acetylsalicylic acid C c- paracetamol D d- indomethacin

Salicylates are used for relief of the following except

A a- headache. B b- visceral pain. C c- toothache. D d- myalgia.

Manifestations of acute salicylate poisoning include

A a- haematemesis & abdominal pain B b- hyperpyrexia. C c-convulsions. D d-all of the above

Aspirin is used in the following except

A a- rheumatic fever B b-bone fracture C c- toothache. D d- myalgia.

The following drug has no anti-inflammatory action

A a- acetylsalicylic acid B b- sodium salicylates C c- diclofenac D d- paracetamol

Children with viral infections should avoid

A a-diclofenac B b-acetylsalicylic acid C c- paracetamol D d- indomethacin

Salicylates act through inhibition of synthesis of

A a- serotonin B b-leukotrienes C c- prostaglandins D d- histamine

Manifestations of acute salicylate toxicity not include

A a- haematemesis. B b-cold moist skin. C c- dehydration. D d- hyperpyrexia

Manifestations of acute salicylate poisoning include

A a- metabolic acidosis. B b-abdominal pain C c- convulsions D d-all of the above.

Salicylates are not effective in the following

A a- bone fracture. B b -dysmenorrhea C c- rheumatic fever. D d- Gout

The following dose of aspirin inhibit platelet aggregation

A a- 150 mg/day. B b- 600 mg/day C c- 3 grams/day D d-10mg/day

Salicylates are contraindicated in the following except

A a- hypoprothrombinemia. B b-peptic ulcer C c- patients taking oral anticoagulants D d-rheumatic fever

Regarding to acetylsalicylic acid, the following is false

A a-it has antipyretic, analgesic&anti-inflammatory effect B b-it is used in a small dose as an antiplatelet drug C c-it is used in small doses as a uricosuric drug in gout. D d- all of the above

Regarding to salicylates, the following are true except

A a- large doses are uricosuric. B b- small doses lead to hyperuricemia C c- small doses of salicylates inhibit platelet aggregation. D d-they have a hypothermic action.

Regarding to salicylates, the following is true

A a-they are contraindicated in peptic ulcer, purpura, haemophilia. B b-they are contraindicated in children viral infections. C c-they have a wide safety margin. D d-all of the above

Regarding to paracetamol, the following is false

A a- it is given orally B b- it is completely absorbed after oral administration. C c- it may be given for patients suffering from peptic ulcer D d- it has a potent antiinflammatory action.

Regarding to paracetamol, the following is correct

A a- it is used mainly as an analgesic or antipyretic. B b- it may induce dose dependent hepatotoxicity. C c- it does not effect the acid- base balance. D d-all of the above

Corticosteroids are used in the following

A a-collagen & rheumatic disease B b-autoimmune diseases. C c-anaphylactic shock & other allergic diseases D d- all of the above.

Pharmacological actions of corticosteroids not include

A a-Anti-inflammatory & antiallergic. B b-fibrinolytic activity C c-Immunosuppressive effect D d-hypoglycemic effect

Corticosteroids inhibit the following enzyme

A a-cyclooxygenase enzyme B b-phospholipase-A2 enzyme C c-lipoxygenase enzyme D d-phosphodiesterase enzyme

Therapeutic uses of corticosteroids include

A a-optic neuritis, allergic conjunctivitis & malignant exophthalmos B b-leukemia and lymphoma. C c-in plastic surgery & organ transplantation D d-all of the above.

Adverse effects of corticosteroids not include

A a-salt & water retention, incrased blood pressure. B b-hypokalemia C c-decreased blood glucose level. D d- osteoporosis& muscle wasting.

Prolonged local use of the following drugs increases the intra ocular pressure

A a- corticosteroids B b- antihistamines C c-tetracycline D d- non of the above

The following corticosteroid is biologically inert

A a- hydrocortisone B b- cortisone C c-prednisolone D d- insuline

Contraindications of corticosteroids include

A a- viral keratitis B b- old TB. C c-hypertension D d-all of the above

Contraindications of corticosteroids include

A a-acute infections B b-psychosis C c-Live viral or bacterial vaccination D d-all of the above.

The following drugs decrease corticosteroids activity

A a-barbiturates B b-carbamazepine C c-rifampicin D d-all of the above

Corticosteroid therapy is practically mandatory in the following condition

A A. Septic shock B B. Renal transplant C C. Rheumatoid arthritis. D D. Ulcerative colitis

The following adverse effect of corticosteroids is mainly due to their mineralocorticoid action

A A. Osteoporosis B B. Rise in blood pressure C c. Increased susceptibility to infection D d. "Moon face

Which of the following bones is affected more by glucocorticoid Induced osteoporosis

A A. Lumber vertebra B B. Humerus C C. Radius D D. Femur

The corticosteroid preferred for replacement therapy in Addison's disease is

A A. Aldosterone B B. Fludrocortisone C C. Hydrocortisone D D. Betamethasone

Hydrocortisone induces the synthesis of the following protein which in turn inhibits the enzyme phospholipase-A2

A A. Heat shock protein-90 B B. Inhibin C C. Transcortin D D. Lipocortin

Aspirin prolongs bleeding time by inhibiting the synthesis of

A A. Clotting factors in liver. B B. Prostacyclin in vascular endothelium C C. Cyclic AMP in platelets D D. Thromboxane A2 in platelets

Inhibition of thromboxane synthesis by aspirin in platelets lasts for 5-7 days because

A A. Aspirin persists in the body for 5-7 days B B. Aspirin induced depletion of arachidonic acid lasts 5-7 days C C. Regeneration of aspirin inhibited cyclooxygenase takes 5-7 days D D. Platelets cannot generate fresh thromboxane synthetase and their turnover time is 5-7 days

Which of the following is an irreversible inhibitor of cyclooxygenase

A A. Aspirin B B. Phenylbutazone C C. Indomethacin D D. Piroxicam

Low doses of aspirin prolong bleeding time by selectively Inhibiting synthesis of the following mediator in the platelets

A A. Thromboxane A2 B B. 5-Hydroxytryptamine C C. Platelet activating factor D D. Prostacyclin

Aspirin is contraindicated in children suffering from influenza or similar viral infection because of increased risk of

A A. Gastric bleeding B B. Thrombocytopenia C C. Fancony syndrome D D. Reye's syndrome

Paracetamol has the following advantage(s) over NSAIDs

A A. It is the first choice analgesic for majority of osteoarthritis patients B B. It can be given safely to all age groups from infants to elderly C C. It is not contraindicated in pregnant or breast feeding women D D- non of the above

Sign in required