Quiz: Bio — AUA MCQ

1. Rate controlling step of pyrimidine biosynthesisis catalyzed by:

A a) Orotidylate decarboxylase B b) Aspartate transcarbamoylase C ec) Carbamoyl phosphate synthase II D d) Orotate phosphoribosyl transferase

2. Which statement for purine biosynthesisis incorrect?

A a) Requires vitamin B12 B b) Assembled on ribose phosphate C c) Requires PRPP D d) Requires glycine

3. Purinesand pyrimidinesare:

A a) Dietary essential B b) Dietary non-essential C c) Derived from essential fatty acids D d) Derivatives of essential amino acid

4. The two nitrogensof the pyrimidine ringare contributed by:

A a) Glutamate and ammonia B b) Glutamate and aspartate C c) Glutamate and glutamine D d) Aspartate and carbamoyl phosphate

5. Nitrogen or carbon atoms are contributed to the structure of the purine ring by amino acids,except:

A a) Glycine B b) Glutamine C c) Aspartate D d) Glutamate

6. Lesch-Nyhansyndromemay lead to:

A a) Self-destructive behavior B b) Gout C c) Elevated levels of PRPP D d) All of the above

7. Hyperuricemiacan result from defect in enzymes,except:

A a) Carbamoyl phosphate synthase II B b) HGPRTase C c) PRPPsynthase D d) Glucose-6-phosphatase

8. The end product of purine metabolism in human is:

A Creatinine B Uric acid C Urea D ) Ammonia

9. The salvage pathway for purines involves enzyme:

A a) PRPPamidotransferase B b) PRPPsynthase C c) HGPRTase D d) Xanthine oxidase

9. The salvage pathway for purines involves enzyme:

A a) PRPPamidotransferase B b) PRPPsynthase C c) HGPRTase D d) Xanthine oxidase

10. Enzyme involved with immunodeficiency disease of purine metabolism is

A a) Adenosine deaminase B b) Xanthine oxidase C c) PRPPsynthetase D d) HGPRTase

11. Purine salvageoccursin the tissues, except:

A a) RBC B b) Brain C c) Liver D d) Polymorphonuclear leukocytes

12. Allopurinol is used in the treatment of:

A Rickets B Cancer C Gout D Pellagra

13. Lesch-Nyhan syndrome is due to the lack of:

A a) HGPRTase B b) APRTase C c) Adenosine deaminase D d) PRPPamidotransferase

14. Hereditary orotic aciduria type II is due to deficiency of the following enzyme

A a) Dihydro-orotate dehydrogenase B b) Orotate phosphoribosyl transferase C c) Aspartate transcarbamoylase D d) Orotidylate decarboxylase

1. The four nitrogen atoms of purinesare derived from:

A a. Urea and ammonia B b. Ammonia, glycine and glutamate C c. Ammonia, aspartate and glutamate D d. Aspartate, glutamine and glycine

2. A drug which prevents uric acid synthesisby inhibiting the enzyme xanthine oxidaseis:

A Aspirin B Allopurinol C Colchicine D Probenecid

3. Glycinecontributesto the following Cand N of purine nucleus:

A a. C-l, C-2, and N-7 B b. C-8, C-6 and N-9 C c. C-4,C-5 and N-7 D d. C-3,C-4 and N-l

4. Inosinicacidis the biologicalprecursor of:

A a. Cytosine and uric acid B b. Adenylic acid and guanylic acid C c. Orotic acid and uridylic acid D d. Adenosine and thymidine

5. The probable metabolic defect in gout is:

A a. A defect in excretion of uric acid by kidney B b. An overproduction of pyrimidines C c. An overproductin of uric acid D d. An underproduction of purine

7. In humans, the principalbreakdown product of purinesis:

A Ammonia B Allantoin C Alanine D e. Uric acid

8. A key substancein the committed step of pyrimidine biosynthesisis:

A . Ribose-5'-phosphate B b. Carbamoyl phosphate C ATPd D Glutamine

9. In humans, the principalcatabolicproduct of pyrimidinesis:

A Uric acid B Allantoin C Hypoxanthine D . p-Alanine

10. In most mammals, except primates, uric acidis metabolisedby:

A a. Oxidation to allantoin B b. Reduction to NH3 C c. Hydrolysis to allantoin D d. Hydrolysis to ammonia

12. Two Nitrogen of the pyrimidine ring are obtained from:

A a. Glutamine and carbamoly-P B b. Aspartate and carbamoly-P C c. Glutamate and ammonia D d. Glutamine and ammonia

13. All are true about Lesch-Nyhansyndrome except:

A a. Produces self-mutilation B b. Genetic deficiency of the enzyme HGPRT C c. Elevated levels of uric acid in blood D d. Inheritence is autosomal recessive

14. Synthesisof GMP from IMP requires the following:

A a. Ammonia, NAD+, ATP B b. Glutamine, NAD+, ATP, C c. Ammonia, GTP, NADP+ D d. Glutamine, GTP, NADP+

15. Which pathway is correct for catabolism of purines to form uric acid?

A a. Guanylate -> Adenylate -> Xanthine -> hypoxanthine -> uric acid. B b. Guanylate -> inosinate -> xanthine -> hypoxanthine -> uric acid C c. Adenylate -> Inosinate xanthine hypoxanthine -> uric acid D d. Adenylate -> inosinate -> hypoxanthine uric acid

1. Chief anion of ECFis:

A Cl B HCO3 C HPO4 D Protein

2. In ICF, main cation is:

A Na+ B K+ C Ca++ D ) Mg++

3. Which of the following is correct about intracellular water (ICW)?

A a) Amount less than ECW B b) Amount more than ECW C WATERMETABOLISM 275 D c) Amount equal to ECW

4. Which of the following hormones affects fluid and electrolyte balance?

A Epinephrine B Glucagon C Thyroxine D Aldosterone

5. Distribution of water between intracellular and extracellular compartments depends on all of the following, except:

A a) Osmolality B b) Osmolarity C c) Colloidal osmotic pressure D d) Surface tension

6. Sourceof daily output of water is:

A a) Urine B b) Insensible water (skin and lungs) C c) Sensible water (sweat and stool) D d) All of the above

7. Metabolic water is:

A a) Water from food B b) Drinking water C c' Water derived from metabolism D d) Total body water

8. Water and electrolyte balanceis regulated by, except:

A a) ADH B b) Renin-angiotensin-aldosterone system (RAAS) C c) Atrial natriuretic factor (ANF) D d) Insulin

9. Main anionsof ICFis:

A Cl B HPO4 C HCO3 D SO4

11. Which of the following hasgreatest water content?

A Liver B Adipose tissue C Brain D Kidney

13. In a 70 kg adult, the total body water content is

A ) 42 L B ) 28 L C 14L D 3.5 L

1. Normal renal plasma flow in healthy adults averages about:

A 125 ml/mt B 200 ml/mt C 450 ml/mt D 574 ml/mt

2. All of the following substanceshave been used to estimate GFR except:

A Inulin B Creatinine C Phenol red D Mannitol

3. Relationship between GFR and serum creatinine concentration is:

A Non-existent B Inverse C Direct D Indirect

4. Normal maximum urea clearance (Cm) in an adult averages about

A . 60 B 65 C 70 D 75

5. In healthy adult the upper limit of normal serum creatinine concentration is

A . 0.75 mg/dl B b. 1.2 mg/dl C c. 2.1 mg/dl d. 2.1 mg/dl D e. 3.5 mg/dl

6. In patients with renal failure all of the following are typically elevated in serum, except

A a. Urea nitrogen B b. Phosphate C c. Uric acid D d. Albumin

7. Excretionof PSPprimarilyreflects:

A a. Liver function B b. Kupffer cell activity C c. Maximal tubular excretory capacity D d. Glomerular filtration rate (GFR)

8. Thenephrotic syndromeincludes,all of the followingexcept

A a. Protein loss of 3 to 3.5 gm/24 hrs or more in urine, B b. Dehydration C c. Elevatedserum cholesterol level D d. Low serum albumin level

8. Thenephrotic syndromeincludes,all of the followingexcept

A a. Protein loss of 3 to 3.5 gm/24 hrs or more in urine, B b. Dehydration C c. Elevatedserum cholesterol level D d. Low serum albumin level

9. Of the following,the firstlaboratoryevidenceof chronicpyelonephritis isoften

A a. Raisedserum uric acid level B b. Raisedserum urea nitrogen level C c. Decreasedcreatinine clearance D d. Lossof concentrating ability

1. Conjugatedhyperbilirubinemia with raisedalkalinephosphataselevels are foundin

A a) Viral hepatitis B b) Obstructive jaundice C c) Hemolytic jaundice D d) Neonatal physiological jaundice

Sign in required