Quiz: Clinical Pathology

1-Which of the following is an autoimmune disease?

A a) Addison’s disease B b) Syphilis C c) Tuberculosis D d) AIDS

2-Majority of auto immune diseases are:

A a) cell mediated B b) mast cell mediated C c) macrophage mediated D d) antibody mediated

Which of the following statements is incorrect regarding Rheumatoid arthritis?

A a) It is an autoimmune disorder B b) It occurs only in old people C c) Inflammation of synovial fluid D d) diagnosis of the presence of rheumatoid factor

Which one of the following is a cell mediated hypersensitivity reaction?

A a) Type I B b) Type II C c) Type III D d) Type IV

What causes peripheral arterial disease (PAD)?

A A. Elevated High-density lipoprotein (HDL) cholesterol B B. Exercise-induced asthma C C.Untreated hypertension D D.Atherosclerosis of the extremities

VLDLs are synthesized in:

A a) blood B b) liver C c) intestine D d) pancreas

High level of which lipoprotein class are associated with decreased risk of accelerated atherosclerosis?

A a) Chylomicrons B b) VLDL C c) LDL D d) HDL

The chemical composition of HDL-cholesterol correspond to?TG Cholesterol :Protein*

A a) 60% 15% 10% B b) 10% 45% 25% C c) 5% 15% 50% D d) 85% 5% 2%

In familial hypercholesterolaemia, the hallmark finding is an elevation of ?

A a) LDL B b) Chylomicrons C c) HDL D d) Apolipoprotein A1

HDLs are synthesized in

A a) blood B b) liver C c) intestine D d) pancreas

What is the major protein constituent of high-density lipoprotein (HDL)?

A a) Apolipoprotein A-l B b) Apolipoprotein C-l C c) Apolipoprotein E D d) None of these

Chylomicrons are synthesized in

A a) blood B b) liver C c) intestine D d)pancreas

Which of the following lipid results would be expected to be falsely elevated on a serum specimen from a non fasting patient?

A a) Cholesterol B b) TG C c) HDL D d) LDL

Through the bloodstream, These are commonest organisms causing meningitis EXCEPT

A a) S.pneumoniae B b) L. monocytogenes. C c) H.infunzae D d) N.meningitidis

Staph. Epidermidis is more expected as cause of meningitis after

A a) blood transfusion B b) hormonal therapy C c) Trauma and Operation D d) corticosteroids

The specimen of choice in diagnosis of meningitis is

A a) Throat swap B b) CSF C c) Blood culure D d) Nasal swap

Inflammation of the membranes of the brain or spinal cord is

A a) Meningitis B b) Encephalitis C c) Myelitis D d) Brain abscesses

Hemophilia A is

A a) Sex–linked disease B b) autosomal dominant C c) autosomal recessive D d) Acquired disease

In Hemophilia A; There is

A a) Prolonged APTT B b) Prolonged PT C c) Increase D dimer D d) Thrombocytopenia

Thrombocytopenia may be caused by

A a) Splenomegaly B b) Active bone marrow C c) Hemoltic anemia D d) Essential thrombocythaemia

Monitoring Therapy of Warfarin by

A b) PT B b) PTT C c) D dimer D d) FDP

In DIC; There is

A a) normal APTT B b) normalPT C c) Thrombocytosis D d) Thrombocytopenia

One of acute Transfusion Complication

A a) Transfusion Transmitted Infection B b) Circulatory Overload C c) Iron Overload D d) Anaphylactic reaction

Common transfusion transmitted pathogens

A Hepatitis ( C,B) B Toxoplasma C Brucella D Salmonella

People with blood group O has antibodies against

A a) O & D antigens B b) A antigen only C c) B antigen only D d) A & B antigens

Storage period of platelet in blood bank

A a) 50 days in the freezer B b) 40 days in the refrigerator C c) 5 days in the refrigerator D d) 5 days at room temperature

Now available as recombinant component

A a) RBCs B b) FFP C c) platelets D d) FVIII

Variation in red cell size observed on the peripheral smear is described as

A A. Anisocytosis B B. Hypochromia C C. Poikilocytosis D D. Pleocytosis

Which of the following are granular WBCs

A A. Eosinophils, Basophils & Neutrophils B B. Lymphocytes & Monocytes C C. Reticulocytes D D. Natural killer cells

Inherited causes of hemolytic anaemia include

A A. von willebrand's disease B B. Phenylketonuria C C. Spherocytosis D D. Paroxysmal nocturnal hemoglobinuria

Causes of microcytic anaemia include

A A. Pernicious anaemia B B. Thalassemia C C. Vitamin C deficiency D D. Hyperthyroidism

Which of the following is the formula for mean corpuscular hemoglobin (MCH)?

A A. Hct / (RBC x 1000) B B. Hb / Hct C C. RBC / Hct D D. (Hb x 10) / RBC

The characteristic erythrocytes present in pernicious anemia is

A A. Microcytic B B. Spherocytic C C. Hypochromic D D. Macrocytic

Reticulocytosis may be indicates

A A. Response to inflammation B B. Neoplastic process C C. Aplastic anemia D D. Effective RBCs production in BM.

Which of the following stains is used for staining reticulocytes?

A A. Supra-vital stains as New methylene blue B B. Giemsa C C. Leishman D D. Prussian blue

Reticulocyte is*

A A. Mature and nucleated RBCs B B. Immature non nucleated RBCs C C. Stained with Leishman stain D D. Smaller than RBCs

Which test is the most suitable for initial testing in suspected thyroid disorders?

A A. Free T3 B B. Free T4 C C. Total T3 D D. TSH

Which of the following statements correctly describes the pathophysiology of Cushing's disease?

A A. Cushing’s disease results from a benign adrenal adenoma secreting excess ACTH. High levels of ACTH in turn cause increased production of cortisol from the adrenal cortex B B. Cushing’s disease results from a benign pituitary adenoma secreting excess levels of cortisol C C. Cushing’s disease results from a benign adrenal adenoma secreting excess levels of cortisol. D D. Cushing’s disease results from a benign pituitary adenoma secreting excess ACTH. Highlevels of ACTH in turn causes increased production of cortisol from the adrenal cortex

In regard to the investigation of hyperthyroidism, which one of the following antibodies is specific to Grave's disease?

A A. TSH receptor antibodies B B. Thyroglobulin antibody C C. Thyroid peroxidase antibody D D. None of these

Serum Somatomedin C assay is a good screening test for diagnosis of

A A. acromegaly B B. Cushing’s disease C C. Diabetes Insipidus D D. pheochromocytoma

ACTH Stimulation is used for diagnosis of

A A. pituitary insufficiency B B. Adrenal insufficiency C C. Adrenal hyperfunction D D. thyroid dysfunction

Which one of the following is NOT a functional test of neutrophils?

A a. The NBT test B b. Cell transformation C c. Bacterial killing D d. Chemotaxis

Congenital complement deficiencies are best screened by which of the following laboratory

A a. Quantitative Immunogloubulins B b. NBT C c. Total CH50 D d. C3,C4 and properdin

Poor skin tests to a range of microbial antigens such as tuberculin and mumps indicate a deficiency of

A a. NK cells. B b. T-cells. C c. B-cells. D d. Phagocytosis.

A deficiency in complement inhibitors could lead to which of the following?

A a. Meningitis B b. Leprosy C c. X-linked hyper-IgM D d. Hereditary angiodema

Investigation of T cell function involves

A a. Enumeration of smlg+ lymphocytes B b. Detection of CD3 T cells only C c. Detection and measurement of cytokine inhibition D d. Phenotype characterization of CD4 and CD8 T cells

B cells predominantly express the following cell markers

A a. CD19 and CD20 B b. CD16 and CD56 C c. CD18 and CD35 D d. CD46 and CD55

Within few weeks of initial HIV infection peripheral blood shows an increase number of

A a. CD8+ T cells B b. Cd9+ T-cells C c. CD10+ T-cells D d. CD11+ T-cells

Defects in neutrophil NADPH oxidase system produce:

A a. Chronic granulomatous disease. B b. Chediak-Higashi disease. C c. Leukocyte adhesion deficiency. D d. Hashimoto's disease.

What is the immunologic consequence of mutation in CD40L (CD154)?

A a. Leprosy and immunity to protozoal infections B b. Acquired immune deficiency syndrome (AIDS) C c. X-linked hyper-IgM syndrome D d. Systemic inflammatory response syndrome (SIRS, sepsis)

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