Quiz: Myelodysplasia

Which one of the following statements about myelodysplasia is false

A A) It predominantly affects elderly individuals B B) It often progress to AML C C) Peripheral blood cytopenias are a characteristic feature D D) BM aspiration reveals a hypocellular marrow

Cytopenia with dysplasia and enhanced apoptosis are features of

A A-AML B B-CML C C-CMML D D-MDS

Which of the following is a feature of myelodysplasias?

A A. Cytopenias B B. Dysmorphic cellular BM C C. Ineffective blood cell production D D. All of the above

Which of the following is false about myelodysplastic syndrome

A A. Idiopathic MDS is a disease of elderly B B. Clonal hematopoietic stem cell disorder C C. Apoptosis of marrow cells increased D D. None of the above

BM in myelodysplasia may show all except?

A A. Normal or hypercellularity B B. Ringed sideroblasts C C. Hypogranulation & hyposegmentation in granulocytic precursors D D. Decrease in myeloblasts

In MDS, prognosis strongly correlates with

A A. Hypogranulation in granulocytic precursors B B. Ringed sideroblasts C C. Proportion of marrow blasts D D. Circulating myeloblasts

Which of the following is not a myelodysplastic syndrome ?

A A. Refractory anemia (RA) B B. Refractory anemia with ringed sideroblasts (RARS) C C. Refractory anemia with excess blasts (RAEB) D D. Acute myelomonocytic leukemia

Which of the following drugs has a role in treatment of MDS ?

A A. Azacytidine B B. Amifostine C C. Lenalidomide D D. All of the above

Sideroblastic anemia usually points to the diagnosis of?

A A. Aplastic anemia B B. Myelodysplasia C C. Pernicious anemia D D. All of the above

The definitive diagnosis for myelodysplasia is

A A- peripheral blood smear B B- blood film C C- BM biopsy D D- iron profile

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