Quiz: SLE — AUA MCQ

1- A 33-year-old woman presents with a malar rash that is exacerbated by sun exposure. She has experienced episodes of myalgia, pleural effusion, pericarditis, and arthralgia without joint deformity over the course of several years. She has a history of hematuria and no history of drug intake prior to the onset of these symptoms. The best screening test for her disease would be:

A A. Antinuclear antibody B B. Anti-ds-DNA antibody C C. Anti-RNP antibody D D. Anti-histone antibody

2- A 32-year-old white woman presents with a 6-week history of fatigue, lymphadenopathy, and low- grade fever. At age 17, she required splenectomy for thrombocytopenia. In her early 20s, she had three miscarriages, one of which was followed by deep vein thrombosis. Which laboratory tests would be most helpful in establishing a diagnosis:

A A. ANA, anti-Sjogren's syndrome (anti-SS-A and anti-SS-B) antibodies B B. Rheumatoid factor, ANA, antiscleroderma (anti-SCL-70) antibodies C C. Antineutrophilic antibodies, antihistone antibodies D D. ANA, anticardiolipin antibodies, and anti-DNA antibodies

3- A 25-year-old female gives birth to a baby with complete heart block who subsequently requires pacemaker insertion. Which of the following antibodies is most likely to be detected in the maternal serum?

A A. Anti-double-stranded deoxyribonucleic acid (dsDNA) antibodies B B. Anti-endomysial antibodies C C. Anti-Ro/SSA antibodies D D. Anti-SCL70 antibodies

4- Which of the following is not included in the American College of Rheumatology (ACR) diagnostic criteria for SLE

A A. Thrombocytopenia B B. Elevated ANA antibody titre C C. Psychosis D D. Alopecia

5- Which of the following is the most common clinically apparent cardiac manifestation of systemic lupus erythematosus?

A A. Myocarditis B B. Libman-Sacks endocarditis C C. Pericarditis D D. Aortic Regurgitation

6- One of the following is not included in the diagnostic criteria for SLE?

A A. Malar rash B B. Libman-Sacks endocarditis C C. Photosensitivity D D. Serositis

- Which one of the following clinical features is most likely to be seen in a patient with SLE?

A A. Uveitis B B. Joint deformity C C. Polyserositis D D.Cavitating lesion in lung

8- The most specific antibody in the diagnosis of SLE is:

A A. A.ANA B B. Anti-RNP C C. Anti-ss DNA D D. Anti-Sm

9- Shrinking lung is a feature of:

A A. SLE B B. Rheumatoid arthritis C C. Scleroderma D D. Sarcoidosis

10- Systemic lupus erythematosus occurs most commonly in:

A A.Children B B. Elderly men C C. Elderly women D D.Women of childbearing age

11- Anti-ds DNA antibody is highly specific for:

A A. Systemic sclerosis B B. SLE C C. Polymyositis D D. Multiple sclerosis

12- Anti-histone antibodies are characteristics of which of the following conditions?

A A. Drug-induced lupus B B. Cardiac lupus C C. Lupus nephritis D D. MCTD

13- Most common pulmonary manifestation in Systemic Lupus Erythematosus (SLE) is ?

A A. Atelectasis B B. Pleuritis C C. Pulmonary vascular disease D D.Infectious pneumonia

14- Antiphospholipid antibodies are found in which of the following immunemediated disorders

A A. SLE B B. Sjogren’s syndrome C C. Behcet’s syndrome D D.RA

15- Skin manifestation of SLE include :

A A. malar rash of skin B C. photosensetivity C D. discoid rash D E. all of the above

16-Which of the following clinical features is least suggestive of systemic lupus erythematosus (SLE)?

A A.Raynaud's phenomenon B B. Scarring alopecia C C. A photosensitive, erythematous malar rash D D. Sclerodactyly

17- Low levels of which one of the following types of complement are associated with the development of systemic lupus erythematous?

A A.C4 B B. C5 C C. C6 D D.C7

18- Which of the following can be a cause of embolic stroke ?

A A. Polycythemia vera B B. Libman-Sacks endocarditis C C. Nephrotic syndrome D D. Sickle cell anemia

19- Which one of the following statements regarding systemic lupus erythematous is true?

A A.It is linked with HLA A5 B B. Onset is typically between 20-40 years old C C. It is more common in Caucasians D D. The female:male ratio is 3:1

20. Which one of the following features is least commonly seen in druginduced lupus?

A A. Glomerulonephritis B B. Arthralgia C C. Myalgia D D. Malar rash

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