Quiz: vasculitis

1- A 40-year-old female, with a known case of asthma for the last four years, presented with a two-month history of numbness in the right upper and both lower limbs. Examination revealed asymmetric neuropathy and palpable purpura over the lower limbs. Investigations revealed eosinophilia. What is the likely diagnosis?

A A. Systemic lupus erythematosus (SLE) B B. Polyarteritis nodosa (PAN) C C. Giant cell arteritis (GCA) D D. Churg-Strauss syndrome

2- A five-year-old girl presents with fever and conjunctivitis. Physical examination is significant for oral erythema and Assuring along with a generalized maculopapular rash and cervical lymphadenopathy. What is the most likely diagnosis?

A A. Henoch- Schonlein purpura B B. Polyarteritis nodosa C C. Kawasaki disease D D. Takayasu’s arteritis

3- All of the following except one are features of Kawasaki disease. Which is the exception?

A A. Peak incidence at > 25 years of age B B. Aneurysm of coronary artery C C. Enlarged lymph nodes D D. Fever

4- A 60-year-old male present with left-sided headache and generalized aches and pains of three months’ duration. For the last three days, he has had slight blurring of the vision from his left eye. The referring doctor has highlighted local tenderness over the left temporal artery and remarkably elevated erythrocyte sedimentation rate. Which of the following is the most likely diagnosis in this patient?

A A. Multiple myeloma B B. Disseminated carcinoma prostate C C. Paget's disease D D. Giant cell arteritis

5- All of the following except one are features of temporal arteritis. Which is the exception?

A A. Polymyalgia rheumatica B B. Anemia C C. Low ESR D D. Sudden blindness

6- A 30-year-old male patient presents with a four-month history of numbness in the right upper and both lower limbs. Examination reveals asymmetric neuropathy, high BP (160/110 mm Hg), normal peripheral pulses, and palpable purpura. Blood tests reveal the presence of HBsAg; however, antinuclear antibody, antibody to ds-DNA, and ANCA are negative. Arteriogram shows multiple aneurysms in the mesenteric and hepatic arteries. The most likely diagnosis is:

A A. Polyarteritis nodosa B B. Systemic lupus erythematosus C C. Wegener's granulomatosis D D. Microscopic polyangiitis

7- A 60-year-old male presents with a left-sided headache and generalized aches and pains of three months’ duration. For the last three days, he has had slight blurring of the vision from his left eye. There is local tenderness over the left temporal artery and an elevated ESR. Which of the following is the most important intervention in this patient?

A A. Serial ESR measurement B B. Temporal artery biopsy C C. Giving 400 mg ibuprofen D D. Giving 60 mg prednisolone

8- All of the following statements except one are true of polyarteritis nodosa (PAN). Which is the exception?

A A. Associated with hepatitis B infection B B. Large-vessel vasculitis C C. Mononeuritis multiplex D D. Associated with hypertension

9- Which of the following is considered the best investigation for diagnosing giant cell arteritis?

A A. Temporal artery biopsy B B. Color Doppler of the temporal artery C C. PET scan D D. MRA

10- Henoch- Schonlein purpura is characterized by the deposition of the following immunoglobulin around the vessels:

A A. IgM B B. IgG C C. IgA D D. IgE

11- Upper respiratory tract infections are common in which one of the following diseases?

A A. Granulomatosis with polyangiitis(Wegner's granulomatosis) B B. Polyarteritis nodosa C C. Systemic lupus erythematosus D D. Giant cell arteritis

12-All of the following except one are examples of small vessel vasculitis. Which is the exception?

A A. Granulomatosis with polyangiitis B B. Microscopic polyangiitis C C. Polyarteritis nodosa D D. Henoch- Schonlein purpura

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